ea0025oc2.1 | Steroids | SFEBES2011
Ahasan Mohammad
, Jones Chris
, Hardy Rowan
, Hassan-Smith Zaki
, Lavery Gareth
, Rabbitt Elizabeth
, Buckley Cristopher
, Raza Karim
, Stewart Paul
, Cooper Mark
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme is a tissue specific regulator of glucocorticoid action that is linked to the development of osteoporosis, inflammatory arthritis and myopathy. Systemic inhibition of 11β-HSD1 enzyme activity has been proposed as a therapeutic option in these conditions. However, 11β-HSD1 activity has also been reported to be important in regulation of the immune response and the HPA axis. We have previously demo...